The Research.
A curated collection of research and reading across the topics that matter most to the Hap House mission. This page will be updated regularly as the science evolves.
A comprehensive review of psilocybin's anti-inflammatory and neuroplastic properties and their potential application in TBI recovery. One of the most thorough examinations of the existing evidence base to date.
Read the study →A peer-reviewed review from Monash University examining how psychedelics interact with the brain following acquired brain injury — including the mechanisms behind neuroplasticity, neuroinflammation reduction, and mood disorder relief.
Read the study →A clinical study from King's College London measuring mental health and brain connectivity outcomes of veterans with TBI following psilocybin retreats. Results showed measurable improvements in both mental health and normalized brain activity.
Read the study →A peer-reviewed review examining how psilocybin's anti-inflammatory, neuroprotective, and neuroplastic properties may address the core mechanisms of TBI — including chronic inflammation, neural network disruption, and comorbid mood disorders.
Read the study →A comprehensive state-of-the-science update from Boston University's CTE Research Center, contextualizing CTE within the broader field of neurodegenerative disease and the latest developments in diagnosis and research.
Read the study →A meta-analysis of 1,000 former contact sport athletes — including American football players — finding a pooled CTE prevalence of 53.7%. A sobering look at how widespread the condition is among those who played.
Read the study →Published in Science by a collaboration between Boston Children's Hospital, Mass General Brigham, and Boston University, this study found that CTE shares genetic mechanisms with Alzheimer's disease — suggesting the condition involves broader biological processes beyond repetitive head impact alone.
Read the study →A peer-reviewed economic analysis finding that psilocybin facilitation at $5,000 or less is cost-effective compared to standard third-line treatments. The upfront investment is higher than a prescription. But the hard costs of years of conventional care for treatment-resistant depression cost more. This study runs those numbers.
Read the study →A cost-effectiveness analysis finding that psilocybin facilitation consistently outperformed standard care — not just on outcomes, but on cost. Research suggests the facilitation protocol generated $7,037 in savings while producing meaningfully better clinical results. The economic advantage held across all price points and time horizons tested, including projections out to 30 years.
Read the study →The leading nonprofit dedicated to ending the suffering caused by concussions and CTE. Offers a free HelpLine, peer support, treatment resources, and connections to the UNITE Brain Bank at Boston University — the world's foremost CTE research institution.
concussionandcte.org →Boston University's CTE Center maintains a dedicated resource page for families dealing with suspected CTE — including guidance on domestic safety, caregiving, and finding specialized support.
bu.edu/cte/resources →Free, confidential crisis support available 24/7. Call or text 988 from anywhere in the US. For anyone experiencing suicidal ideation, emotional distress, or acute mental health crisis — including those living with CTE and brain injury.
988lifeline.org →CTE can contribute to aggression and behavioral changes that put families in danger. If you or someone in your household is at risk, help is available 24/7. Call 1-800-799-7233 or text START to 88788.
thehotline.org →This page is updated regularly. If you have a study or resource to recommend, reach out through the contact page.